Correction: Calcitonin Gene-Related Peptide-Exposed Endothelial Cells Bias Antigen Presentation to CD4+ T Cells toward a Th17 Response.

Ding, W., L. L. Stohl, L. Xu, X. K. Zhou, M. Manni, J. A. Wagner, and R. D. Granstein. 2016. Calcitonin gene-related peptide-exposed endothelial cells bias antigen presentation to CD4+ T cells toward a Th17 response. J. Immunol. 196: 2181-2194. In the original article, the authors incorrectly labeled the x-axes of all graphs in Fig. 8. The BMDCs label should have been pDMECs, and the LC+TC label should have been BMDCs+TC. The labels have been corrected in the figure shown below. The legend for Fig. 8 was correct as published and is shown below for reference. FIGURE 8.CGRP pretreatment of pDMECs biases BMDC Ag presentation to T cells toward an enhanced IL-17A and IL-6 response with a reduced IFN-γ and IL-22 response. Medium- or CGRP-treated pDMECs were added to cultures of BMDCs, T cells (from DO11.10 Tg mice) and cOVA323-339. After 48 h, supernatants were assessed for cytokine content. The addition of medium-treated pDMECs slightly but significantly enhanced IL-17A and IFN-γ (very slightly) production alone with more substantial and significant increases in IL-6 and IL-22. A significant decrease in IL-4 production occurred. The addition of CGRP-treated pDMECs led to a significant increase in IL-17A and IL-6 production and a small but significant decrease in production of IFN-γ and IL-22, with little or no reduction in IL-4 production compared with that seen in wells with addition of medium-treated pDMECs. n = 3 experiments, all groups. *p < 0.05, **p < 0.01, ***p < 0.001.