Feil Family Brain & Mind Research Institute

Publications

Found 25 results
Author Title Type [ Year(Desc)]
Filters: Keyword is Alzheimer Disease  [Clear All Filters]
2014
Hu X, Li X, Zhao M, Gottesdiener A, Luo W, Paul S.  2014.  Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40.. Mol Neurodegener. 9:52.
Ishii M, Wang G, Racchumi G, Dyke JP, Iadecola C.  2014.  Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide Y neurons.. J Neurosci. 34(27):9096-106.
2015
Ishii M, Iadecola C.  2015.  Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology.. Cell Metab. 22(5):761-76.
Luo W, Liu W, Hu X, Hanna M, Caravaca A, Paul SM.  2015.  Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.. Sci Rep. 5:11161.
2016
Del Prete D, Rice RC, Rajadhyaksha AM, D'Adamio L.  2016.  Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.. J Biol Chem. 291(33):17209-27.
Koizumi K, Wang G, Park L.  2016.  Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations.. Cell Mol Neurobiol. 36(2):155-65.
Zhao L, Gottesdiener AJ, Parmar M, Li M, Kaminsky SM, Chiuchiolo MJ, Sondhi D, Sullivan PM, Holtzman DM, Crystal RG et al..  2016.  Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.. Neurobiol Aging. 44:159-172.
McGuire MJ, Ishii M.  2016.  Leptin Dysfunction and Alzheimer's Disease: Evidence from Cellular, Animal, and Human Studies.. Cell Mol Neurobiol. 36(2):203-17.
Yuan P, Condello C, C Keene D, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J.  2016.  TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.. Neuron. 90(4):724-39.
Iadecola C.  2016.  Vascular and Metabolic Factors in Alzheimer's Disease and Related Dementias: Introduction.. Cell Mol Neurobiol. 36(2):151-4.
2022
Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK et al..  2022.  Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.. Mol Neurodegener. 17(1):41.
Yan Y, Wang X, Chaput D, Shin M-K, Koh Y, Gan L, Pieper AA, Woo J-AA, Kang DE.  2022.  X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women.. Cell. 185(21):3913-3930.e19.
2023
Kumar A, Karuppagounder SS, Chen Y, Corona C, Kawaguchi R, Cheng Y, Balkaya M, Sagdullaev BT, Wen Z, Stuart C et al..  2023.  2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience.. Neuron. 111(18):2831-2846.e10.
Luo W, Qu W, Gan L.  2023.  The AD odyssey 2023: Tales of single cell.. Cell. 186(20):4257-4259.
Das M, Mao W, Voskobiynyk Y, Necula D, Lew I, Petersen C, Zahn A, Yu G-Q, Yu X, Smith N et al..  2023.  Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.. Neurobiol Dis. 186:106263.
Uekawa K, Hattori Y, Ahn SJi, Seo J, Casey N, Anfray A, Zhou P, Luo W, Anrather J, Park L et al..  2023.  Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress.. Mol Neurodegener. 18(1):73.
Yang X, Wen J, Yang H, Jones IR, Zhu X, Liu W, Li B, Clelland CD, Luo W, Wong MYing et al..  2023.  Functional characterization of Alzheimer's disease genetic variants in microglia.. Nat Genet. 55(10):1735-1744.
Eruysal E, Ravdin L, Zhang C, Kamel H, Iadecola C, Ishii M.  2023.  Sexually Dimorphic Association of Circulating Plasminogen Activator Inhibitor-1 Levels and Body Mass Index with Cerebrospinal Fluid Biomarkers of Alzheimer's Pathology in Preclinical Alzheimer's Disease.. J Alzheimers Dis. 91(3):1073-1083.
Evering TH, Marston JL, Gan L, Nixon DF.  2023.  Transposable elements and Alzheimer's disease pathogenesis.. Trends Neurosci. 46(3):170-172.
2024
Cheng F, Wang F, Tang J, Zhou Y, Fu Z, Zhang P, Haines JL, Leverenz JB, Gan L, Hu J et al..  2024.  Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer's disease.. Cell Rep Med. 5(2):101379.
Santisteban MM, Iadecola C.  2024.  A deeper dive into amyloid clearance by meningeal lymphatic vessels.. Nat Cardiovasc Res. 3(4):407-409.
Kauwe G, Pareja-Navarro KA, Yao L, Chen JH, Wong I, Saloner R, Cifuentes H, Nana AL, Shah S, Li Y et al..  2024.  KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.. J Clin Invest. 134(3)
Lopez-Lee C, Kodama L, Fan L, Zhu D, Zhu J, Wong MYing, Ye P, Norman K, Foxe NR, Ijaz L et al..  2024.  Tlr7 drives sex differences in age- and Alzheimer's disease-related demyelination.. Science. 386(6725):eadk7844.
Uekawa K, Anfray A, Ahn SJi, Casey N, Seo J, Zhou P, Iadecola C, Park L.  2024.  tPA supplementation preserves neurovascular and cognitive function in Tg2576 mice.. Alzheimers Dement. 20(7):4572-4582.
Qu W, Lam M, McInvale JJ, Mares JA, Kwon S, Humala N, Mahajan A, Nguyen T, Jakubiak KA, Mun J-Y et al..  2024.  Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator.. Acta Neuropathol. 147(1):107.