Dec 5 2019 - 4:00pm to 5:00pm
Location: A-250 Estabrook Lecture Hall
Presenter Steve McCarroll and the scientists in his lab use DNA to understand human biology and disease. They have discovered ways that genes and alleles shape human biology – from cancer (clonal hematopoiesis) to schizophrenia (complement component four genes). Many of their discoveries involve unexpected insights arising from new ways of analyzing biological systems and human DNA. The lab members also develop technologies (such as Drop-seq) that turn aspects of biology into “big data”...
Nov 22 2019 - 12:00pm to 1:00pm
Location: Feil Family Research Building
"National Institute of Neurological Disorder and Stroke (NINDS) Funding Strategies and Updates" Francesca Bosetti, Pharm.D., Ph.D. Stroke Program Director Neural Environment Cluster National Institutes of Health (NIH) NINDS William P. Daley, Ph.D. Scientific Program Analyst NIH NINDS
Nov 22 2019 - 12:00pm
Speaker: Francesca Bosetti, Pharm.D., Ph.D., Stroke Program Director, Neural Environment Cluster, and William P. Daley, Ph.D., Scientific Program Analyst, National Institute for Neurological Disorders and Stroke, NIH
Location: Feil Family Research Building Conference Room 108
Nov 21 2019 - 4:00pm to 5:00pm
Location: Weill Auditorium
How do some neurons survive a lifetime while others succumb to neurodegeneration? We take a ‘bottom-up’ approach to this question by first understanding the molecules and pathways that control neuronal survival, and then work upstream to ask how cellular stresses including misfolded proteins, physical injury and loss of neurotrophic support disrupt these pathways to promote degeneration. A particular focus has been on survival of the axon, the long cable-like structures that connect neurons and...
Nov 15 2019 - 12:00pm to 1:00pm
Location: Feil Family Research Building
"Introduction to Clinical Neurology for Neuroscientists: A Live Patient Case Presentation" Makoto Ishii, M.D., Ph.D. Assistant Neuroscience and Neurology Professor Brain & Mind Research Institute (BMRI) Weill Cornell Medicine Neurology
Nov 15 2019 - 12:00pm
Speaker: Makoto Ishii, MD, Ph.D., Assistant Professor of Neurology and Neuroscience, Department of Neurology and BMRI, WCM (B2B)
Location: Feil Family Research Building Conference Room 108
Nov 14 2019 - 4:00pm to 5:00pm
Location: Weill Auditorium
We have recently shown that brain capillaries act as a neural activity-sensing network by initiating and transmitting an electrical signal, mediated by potassium channel activation that propagates through the interconnected endothelial cells comprising the capillaries that line all blood vessels. This concept explains the rapid and coordinated delivery of blood to active neurons. Using a mouse model of a monogenic form of Singular Value Decomposition (SVD), we have discovered early defects that...
Nov 8 2019 - 12:00pm to 1:00pm
Location: Feil Family Research Building
"Fostering Lysosomes to Treat Alzheimer’s Disease" Santiago Sole Domenech, Ph.D. Biochemistry Research Associate and Fellow Weill Cornell Medicine
Nov 8 2019 - 12:00pm
Speaker: Santiago Sole Domenech, Ph.D., Maxfield Laboratory, Research Associate in Biochemistry, Department of Biochemistry, WCM (Leon Levy Fellow)
Location: Feil Family Research Building Conference Room 108
Nov 7 2019 - 4:00pm to 5:00pm
Location: Weill Auditorium
Our group has a long-standing research program concerning the use of genetics as well as biochemical and behavioral approaches in the study of neurodegeneration with a focus on the human disease SpinoCerebellar Ataxia type 1 (SCA1). In collaboration with Huda Zoghbi at Baylor, we cloned the SCA1 gene - the first genetically defined ataxia. We went on to establish the first transgenic mouse model of a polyglutamine disease. This model is the center of continued studies on the normal function of...