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The 10th annual Appel Alzheimer's Disease Research Institute Symposium brought fascinating reports of progress in understanding Alzheimer’s and related neurodegenerative diseases. The event was held at the Belfer Research Building on Oct. 25, before an in-person and Zoom audience.

Sponsored by Weill Cornell Medicine’s Helen and Robert Appel Alzheimer’s Disease Research Institute and its home department, the Feil Family Brain and Mind Research Institute, the event offered four...

Aggregates of the protein alpha-synuclein spread in the brains of people with Parkinson’s disease through a cellular waste-ejection process, suggests a new study led by Weill Cornell Medicine researchers.

During the process, called lysosomal exocytosis, neurons eject protein waste they cannot break down and recycle. The discovery, published Aug. 22 in Nature Communications, could resolve one of the mysteries...

As mice navigate different rooms in virtual reality, the prefrontal neurons (top) communicate with those in the hippocampus (bottom) to conjure associated memories. Video courtesy of Nakul Yadav. From Yadav, N., Noble, C., Niemeyer, J.E. et al. Prefrontal feature representations drive memory recall. Nature (2022...

Inhibiting an important signaling pathway in brain-resident immune cells may calm brain inflammation and thereby slow the disease process in Alzheimer’s and some other neurodegenerative diseases, suggests a study by Weill Cornell Medicine investigators. The findings point to the possibility of new therapeutic strategies against neurodegenerative diseases, which are relatively common in older adults and so far have no effective, disease-modifying treatments.

Brain inflammation,...