News

Study Brings Neuroscience a Step Closer to a High-Resolution Mammalian Brain Atlas

illustration of cells in the body

A team led by scientists at Weill Cornell Medicine has made a map identifying all the different RNA molecules that are derived from each gene in the brains of mice. It is the first map that depicts this important layer of biological diversity, called isoform variation, by cell type and across brain regions for the whole genome, and it contributes to neuroscientists’ ambitious goal of an ultra-detailed atlas of the brain.

Isoform variation is a process that extends the versatility of...

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Center for Neurogenetics at Weill Cornell

CNG Video image

The Center for Neurogenetics was featured in the American Society of Human Genetics (ASHG) Annual Meeting October 6-10, 2020.

The Center for Neurogenetics (CNG) is a translational research hub that brings together clinicians, geneticists, neuroscientists, patients and family members to seek the underlying genetic contributions to and advanced therapeutics for disorders of the nervous system.

https://...

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Academic Year 2020

Drs. Anna and Adam Orr (PIs)

Daedalus Fund for Innovation of Weill Cornell Medicine BP 214689-01
Site-Specific Blockers of Mitochondrial FreeRadicals for Therapeutic Intervention in Neurodegenerative Diseases

Marilena D'Aurelio (PI)
National Institute of Neurological Disorders and Stroke 1R21NS118233-01A1
Modulation of intermediate metabolism, a new therapeutic approach for mitochondrial encephalomyopathies...

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Alzheimer’s-Related Tau Protein Can Disrupt Blood Flow in the Brain, Long Before Neurodegeneration Sets In

image of cells

Abnormal forms of a brain-cell protein called tau, which have long been implicated in Alzheimer’s and other neurodegenerative disorders, may contribute to neurodegeneration earlier than was previously understood, by interfering with the normal dynamics of blood flow in the brain, suggests a study from scientists at Weill Cornell Medicine. The results pave the way for research efforts that seek to prevent early neurodegeneration by restoring normal blood flow.

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Doctors Detail Unexpected Recoveries from Long-Term Coma After Cardiac Arrest

brain eeg scan

Neurologists traditionally have expected that patients who remain in coma after cardiac arrest have almost no chance of making a meaningful recovery if they fail to emerge from coma within a week. But a new study from Weill Cornell Medicine, NewYork-Presbyterian and NYU Grossman School of Medicine neurologists suggests that a small but significant fraction of such patients can recover even after much longer periods of coma...

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African American Patients Have Higher Risk of Stroke Recurrence Compared with White Patients

Man leaning against wall in front of window

The short-term risk of a second stroke following an initial minor stroke is roughly 60 percent higher for black patients compared with white patients, according to a study led by Weill Cornell Medicine and NewYork-Presbyterian researchers.

In the study, published Feb. 24 in JAMA Neurology, the researchers re-analyzed the results of a stroke prevention trial conducted at 269 sites worldwide, including...

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Sex Differences in Susceptibility to Neurodegenerative Disease May Arise From Differences in Brain Immune Cells

Immune cell activity in the brain differs between males and females in ways that may explain why some neurodegenerative diseases affect the sexes differently, according to a new study from Weill Cornell Medicine scientists.

The study, published Dec. 23 in Nature Neuroscience, compared brain-resident immune cells called microglia in male and female mice. Microglia in Alzheimer’s disease and other neurodegenerative disorders...

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Brain Immune Cells, Neurodegeneration Differ in Males, Females

Dr. Li Gan in her lab

Immune cell activity in the brain differs between males and females in ways that may explain why some neurodegenerative diseases affect the sexes differently, according to a new study from Weill Cornell Medicine scientists.

The study, published Dec. 23 in Nature Neuroscience, compared brain-resident immune cells called microglia in male and female mice. Microglia in Alzheimer’s disease and other neurodegenerative disorders...

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Developmental Deficits in GABA Lead to Abnormal Brain Rhythms in Sensory Areas

Dr. De Marco Garcia

Decreased amounts of a neurotransmitter called GABA, whose main function is to reduce activity in the brain, leads to changes in the number of neurons in the developing brain and alters signaling between them, according to new research by Weill Cornell Medicine investigators. The findings could lead to an improved understanding of autism and sensory processing disorders.

There are two kinds of neurons in the cortex: Excitatory neurons “fire” and pass signals on to other neurons and...

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